Pathophysiology

Pathophysiology

Dengue viral infections frequently are not apparent. Classic dengue primarily occurs in nonimmune, nonindigenous adults and children. Symptoms begin after a 5- to 10-day incubation period. DHF/DSS usually occurs during a second dengue infection in persons with preexisting actively or passively (maternally) acquired immunity to a heterologous dengue virus serotype. Illness begins abruptly with a minor stage of 2-4 days' duration followed by rapid deterioration. Increased vascular permeability, bleeding, and possible DIC may be mediated by circulating dengue antigen-antibody complexes, activation of complement, and release of vasoactive amines. In the process of immune elimination of infected cells, proteases and lymphokines may be released and activate complement coagulation cascades and vascular permeability.

The grade of fever
Low grade fever: 37.3~38 C
Moderate fever: 38~39 C
High fever: 39.1~41 C
Hyperthermia fever: more than 41 C
-Fever to 106°F (41.1°C), which a healthy adult body can tolerate for several hours.
-The brain's thermostat will stop the fever from climbing above 106° (41.1C)
-Cells do not die off until 110°F (43.3°C) is reached.